Endocrine Abstracts

Abnormal growth patterns are commonly observed in children suffering from chronic inflammatory diseases. These disorders are associated with the increased production of pro-inflammatory cytokines, which inhibit growth plate chondrocyte dynamics. Ceramide, a sphingosine-based lipid second messenger, mediates many of the actions of pro-inflammatory cytokines. Ceramide inhibits IGF-1 signalling and induces apoptosis in numerous cell types. This study determined the effects of C2-...

Background: Inflammatory cytokines in children with juvenile idiopathic arthritis (JIA) may modulate growth through systemic and local mechanisms.Aims: To study the relationship between inflammatory cytokines in serum /synovial fluid (SF) with growth and to assess the effects of serum/SF on the fetal rat metatarsal model.Subjects & Methods: 17 children with JIA (F,10): 8 oligoarticular, 2 extended oligoarticular, 6 polyarticula...